Brand Name:Apo-Glyburide, Diabeta, Gen-Glybe, Nu-Glyburide, PMS-Glyburide, ratio-Glyburide, Rhoxal-glyburide

Prescription needed: Yes

What is this drug used for?

Glyburide is used along with diet and exercise to treat type-2 diabetes. It works by stimulating the pancreas to make more insulin which reduces blood glucose levels.

Is there any reason not to take this drug?

You should not use this drug if you are allergic to it or to any of its ingredients or to other sulfonylureas or sulfonamides. As well, do not take it unless you have type-2 diabetes. Tell your doctor specifically if you have or have ever had kidney disease or ketoacidosis, a serious condition where the body has dangerously high levels of ketones -- or acids that build up in the blood or severe renal of hepatic insufficiency.

What about possible side effects?

Oral hypoglycemic drugs have been associated with increased risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin.

Tell your doctor of any and all side effects that you experience while taking this drug, including:

  • constipation
  • diarrhea
  • sweating
  • faintness
  • confusion
  • tremours
  • nausea
  • vomiting
  • rash
  • itching
  • jaundice
  • weight changes

Glyburide may also cause other side effects. Call your doctor if you have any unusual problems while taking this medication. As well, be aware of the symptoms of high and low blood sugar.

What if I am taking other drugs?

Always provide your doctor with a list of all other drugs you are taking (including over-the-counter medications) as they may interact with another drug, increasing or decreasing effectiveness and safety of either or both. Tell your doctor specifically if you are taking any of these drugs:
  • anti-coagulants
  • corticosteroids
  • estrogen
  • diuretics
  • rifampin
  • sulfonamides
  • antibacterials
  • ASA
  • beta blockers
  • ACE inhibitors

Other information:

Regularly check your urine and blood sugar.

Children: Not prescribed.

Seniors: There is an increased risk of hypoglycemia. Reduced dose may be necessary.

Pregnant women: Not usually prescribed. Instead, your doctor may substitute insulin as it will provide tighter control.

Women who are nursing: Safety not established. Talk to your doctor.

People who drive or operate machinery: Should not do so until they know the impact this drug has on them personally. This drug may cause low blood sugar, dizziness, drowsiness and confusion.

Overdose: Too much glyburide can cause your blood sugar levels to drop dangerously low. Know your own symptoms of hypoglycemia and treat them quickly. If you experience any unusual reactions or if you seriously exceed the recommended dosage, call your doctor or 911.

Stopping the drug: Always talk to your doctor before you stop taking this drug. If you stop taking this medicine, you may not be able to control your blood glucose levels.

If you miss a dose: Take it the next time you eat. Never take a double dose.

Storage conditions: Closed container; cool, dry location away from excess moisture (not in the bathroom); always out of reach of children.

Alcohol: Alcohol increases blood sugar; if you drink, drink in moderation.

Dietary precautions: Follow your doctor’s recommendations. In order to keep your blood glucose levels in control, you need to balance your medicine with the right amount of food and exercise.